October 2007
Visit Chemical Information Services at CPhI

Chemical Information Services (CIS) will be at CPhI Worldwide in Milan, Italy from October 2nd to the 4th. Come visit us at stand 9A34 at the Fiera Milano Rho Exhibition Centre. We will be featuring our Directory of World Chemical Producers (DWCP), PathFinder Catalogue of Chemical Intermediates, Worldwide Bulk Drug Users Directory (WBDU) and the Worldwide Contract Manufacturers Directory (WCMD). CIS also sponsors and provides the information for the Raw Materials Section of Wayfinder, which allows visitors to find out which exhibitors at the show produce specific raw materials (bulk pharmaceuticals, intermediates, fine chemicals, etc.)

 

Famous Quotes of the Month

- It takes 20 years of hard work to become an overnight success. (Diana Rankin)

- Experience is the name everyone gives to his mistakes. (Oscar Wilde)

- A positive attitude may not solve all your problems, but it will annoy enough people to make it worth while. (Herm Albright)

- You can't wait for inspiration. You have to go after it with a club. (Jack London)

- I fight every day, but who said a fight has to be tongue and feet? You fight by showing you can overcome. (Mookie Wilson)
 

 



 

 
Why does seawater appear blue?
Seawater appears blue because it absorbs all wavelengths of light except for the shorter blue wavelengths, which it effectively scatters. The light attenuation is caused by the combined absorption and scattering properties of everything in the water (inorganic particulates and dissolved matter), as well as the water itself. Plankton has the greatest effect on the color of seawater. Tropical oceans have very little suspended sediment and plankton and are very clear and have an azure blue color. Cooler, temperate ocean regions are plankton-rich and appear more greenish blue.

 



 

 
2006 was a Good Year for Top Chemical Companies
Most of the large chemical companies increased both sales and profits in 2006, with European firms outperforming those in North America. Growing demand and price increases offset climbing energy and feedstock costs. According to ICSI, the top 20 companies saw sales increase by 14 percent with operating profits up by 6 percent compared to 2005. Companies to watch for the rest of 2007 and into 2008 include Sabic, Basell, Dow Chemical, Hexion Specialty Chemicals, Akzo Nobel, PPG Industries, DuPont, ChemChina Group and Chemtura.

 



 
Chemical Industry Concerned by High Court Damage Awards
The American Chemistry Council and other manufacturing industries have expressed concern about two recent court decisions resulting in very large punitive damage awards. Continental Carbon was ordered to pay $17.5 million (Euro 12.4 million) in punitive damages in addition to $3.2 million to cover actual damages, clean-up costs and legal fees for causing property damage as a result of venting of carbon black. No personal injuries were caused by the release.

The ACC and the National Association of Manufacturers (NAM) argue that the punitive damage awards are "grotesquely excessive" considering the circumstances of each case and the level of actual damages paid. They are asking the Supreme Court to provide guidance to lower courts on what constitutes reasonable punitive awards.


In the second case, ExxonMobil was ordered to pay $2.5 billion (the US 9th Circuit Appellate Court reduced the initial $5 billion award by 50 percent) in punitive damages relating to the 1989 Exxon Valdez ship grounding. ExxonMobil has already paid $3.4bn in actual damages, fines and remediation expenses related to the oil spill.
 

 



 
Mexico Passes Tax Law Opposed by Chemical Industry
The Mexican legislature passed a new corporate tax law, the 'flat-rate business tax' or IETU, that raises business tax rates to 16.5 percent of earnings in 2008, 17 percent in 2009 and 17.5 percent in 2010 and beyond. Allowable deductions will include expenses, regional and bank deposit taxes, fines, unpaid trade credits and charity contributions. The chemical industry in the country lobbied against the tax as double taxation on top of the federal income tax and indicated it would significantly erode profits. Pemex, state oil-to-petrochemicals monopoly Petroleos Mexicanos, already pays taxes worth about 6 percent of Mexico's gross domestic product, which has restricted investment in petrochemicals. Mexican President Felipe Calderon Hinojosa must ratify the measure.

 



 
U.S. House Passes Patent Reform Act
The U.S. House of Representative passed the Patent Reform Act of 2007 that will bring changes to the patent system desired by information technology companies and disapproved of by the pharmaceutical and biotech industries. The bill makes many changes including switching the U.S. from a 'first to invent' to 'first to file' system, modifying the way damages are calculated and granting broader rulemaking authority to the Patent and Trademark Office. Others opposing the bill include small inventors, labor unions and the Bush administration.

 



 

 
BP Settles with Plaintiffs from Explosion Trial
In the 11th day of its trial, BP reached an agreement with four plaintiffs that brought civil suits against the company for injuries related to the explosion at its Texas City plant in 2005. These cases were the only ones to make it to trial. The amount of the settlement was not disclosed. BP previously settled 1,600 other cases. Another 1,200 lawsuits connected to the event remain to be settled. The company has set aside $1.6 billion to cover the costs of the lawsuits resulting from the accident.

 



 
Evonik is New Name on the Block

RAG changed its name to Evonik Industries and will pursue an initial public offering in the first half of 2008. Its chemical business Degussa will take the same name. The company also announced that is will invest heavily in its solar silicon business to develop products for the solar energy market. The first project is the construction of the first integrated solar silicon manufacturing facility with partner The Silicon Mine.

 



 
J&J Takes Red Cross to Court

The American Red Cross (ARC) has been using its symbol since the late 1800's, having been granted permission by Johnson & Johnson (J&J), which began using the "Red Cross" symbol and words several years prior. There has not been a problem until recently. J&J has filed a law suit against the ARC because the ARC has been licensing the J&J trademarked Red Cross to products made and sold by a third party. J&J seems to have put itself in a "no-win" situation. The ARC made only $2 million on the sale of these products in 2006. That doesn't mean its actions are acceptable. But whether it wins or not, J&J does not look good as a $50 billion company taking on a charitable organization.

 



 
Lanxess Looks to Asia

Lanxess plans to invest $1.4 billion (Euro 1 billion) within the next three years, with a focus on Asia. Three-fifths of the capital expenditures are earmarked for capacity expansions, while acquisitions will be pursued if they can create value within three years or less. One possible project is a new Butyl rubber plant to come on stream in 2010 in Singapore, Thailand or Malaysia. A decision will be made on the facility by the end of 2007. The company also announced that is will meet is 2009 earnings targets a year early.

 



 
Restructuring Announced by DSM
In order to focus on life sciences and materials, DSM will sell off its Melamine, Urea, fertilizers, energy elastomers, specialty products and Maleic anhydride operations, all with sales worth about $2 billion (Euro 1.4 billion). It is also seeking a partner for its Citric acid business. The company hopes to complete the divestments by 2010 as part of its Vision 2010 strategy.

 



 
Rohm and Haas Company Restructures

Rohm and Haas Company will eliminate 200 jobs through the closure of its digital imaging business in Bristol, PA. The restructuring plan will also include reductions of administrative and business service operations, improvement of manufacturing efficiencies and the consolidation of R&D activities. The actions are expected to save $15 million per year beginning in mid-2008. Separately, over the next five years, the company will invest $100 million (Euro 70 million) in India with the goal of achieving annual sales of $250 million by 2012. The expenditure will include establishment of a technology center in Maharashtra and an acrylic emulsions plant in northern India. Doubling of production capacity at an acrylic emulsions plant in Taloja is already underway. Other expected growth areas include ion exchange resins, biofuels and electronic materials.

 



 
Sigma-Aldrich Invests in China, Israel
Sigma-Aldrich Fine Chemicals announced that it will invest approximately $25 million to build its first manufacturing plant in China, a large-scale non-GMP facility in Wuxi. The plant is expected to start operations in the fourth quarter of 2008. The company then expects to double its initial investment with expansions over the next few years. Products will target the pharmaceutical and electronics markets.

Separately, SAFC announced that it will invest $29 million (Euro 21 million) to expand its high-potency biologics facility in Jerusalem, Israel in order to provide process development and GMP manufacturing for large scale active pharmaceutical ingredients. The expansion is expected to be completed by the first quarter of 2009.
 

 



 
Solutia to Move Out of Bankruptcy

Solutia announced that it will file a consensual plan of reorganization that will prepare the company to emerge from bankruptcy by the end of 2007. The revised plan includes $250 million of new investments, reallocation of legacy liabilities assumed when the company was spun off, and resolution of litigation between the settling parties including Monsanto and Pharmacia. The prior agreement with Monsanto that Monsanto will accept financial responsibility for tort litigation and environmental remediation remains a part of this settlement.

 



 
U.S. Private Equity Invests in China

U.S. Private equity firm The Blackstone Group, which is partly owned by the Chinese government (9 percent, $3 billion), has agreed to invest up to $600 million (Euro 438 million) for a 20 percent stake in the state-owned chemicals producer China National Blue Star (Group) Corp., a wholly-owned subsidiary of ChemChina. Blue Star plans to become more globalized and increase its rate of development through strategic foreign investments. Areas for growth include silicones, animal feed, engineering plastics and coatings for cars. Financial backing from Blackstone and access to global markets will be a first step towards these goals.

 



 

 
Congress Passes New FDA Drug Safety Bill
The bill renews for five years programs to collect fees from drug and medical device producers to fund FDA product review programs and also gives the agency the power to require further safety studies by drug makers and mandate label warning changes when problems with marketed drug products occur. The FDA could also issue fines for non-compliance with these requirements and if companies do not complete follow-up studies once drugs receive approval. The agency would itself be required to more actively monitor drug safety of commercial products. Clinical trial results at some level will also be made public.

 



 
Pharma Top Ten Hold On
Pfizer managed to hold on to the number one spot as the largest pharma company, while GlaxoSmithKline (GSK) pushed past Sanofi-Aventis to take the number two position, according to Wood Mackenzie. Roche climbed from firth to eighth place, while Eli Lilly booted Bristol-Myers Squibb out and returned to the top ten. The global pharmaceutical industry is estimated to have grown by 6.5 percent in 2006, with an annual compound annual growth rate from 2006 to 2013 predicted to be lower at 4.3 percent. Companies with strong pipelines and prospects in biologics will fare best.

 



 
Tremendous Growth Predicted for Indian Pharma Market
McKinsey & Co. predicts that the Indian pharmaceuticals market grow from $6.3 billion in 2005 to $20 billion in 2015, at which point India will be one of the top 10 global pharma markets. The rapid growth is attributed to growing disposable incomes and an expanding middle class combined with greater access to health care and health insurance and an increase in chronic diseases. Small and medium-sized Indian pharma companies are reaping the largest benefits and achieving excellent market penetration.

 



 

 
Petronas Expands Position in Lubricants

Malaysia based Petronas, pursuing its goal of becoming a leading global player in the lubricants market, announced that it will acquire FL Selenia, a major European lubricant manufacturer, for approximately $1.4 billion (Euro 1 billion). FL Selenia serves customers in Europe, South America and the U.S. with lubricants, and transmission, anti-freeze and functional fluids for a variety of vehicles and machinery. The purchase will provide Petronas with a captive market for base oils to be produced at its new plant in Malacca, which is expected to come on-stream by the end of 2008.

 



 
PPG Divests Businesses
PPG Industries announced the sale of its fine chemicals and auto glass businesses. ZaCh System, a subsidiary of Zambon, has agreed to pay $65 million (Euro 47 million) for the fine chemicals business, while Platinum Equity will pay $500 million (Euro 360 million) for the glass operations. The transactions are expected to be complete by the end of the fourth quarter of 2007. With these divestments, PPG has taken the necessary steps to focus on becoming a leading coatings and specialty products and services company, according CEO Charles Bunch.

 



 

 
Monsanto, Iowa State University Settle Soybean Patent Dispute

Monsanto reached an agreement with the Iowa State University Research Foundation (ISURF) to settle a patent infringement lawsuit the group filed against the company regarding low-linolenic acid content soybean. Monsanto stated that it developed the technology independently but worked to reach an agreement with ISU in order to avoid litigation. Monsanto will receive a commercial license from ISURF for current and future low linolenic acid product lines developed by Iowa State University. The University will receive a research license for the use of Roundup RReady2Yield soybeans. Monsanto hopes to collaborate with the university in the future. Low-linolenic acid soybeans have greater shelf-life and make it possible to avoid the need for hydrogenation, which produces unwanted trans fats.

Separately, Iowa's attorney general's office has requested information regarding Monsanto's seed, trait, and chemistry related licensing and marketing programs as part of an inquiry into possible antitrust violations by the company. Monsanto is providing information and will make it available to any state attorneys general.
 

 



 

 
Generic Biologics Soon to be Real Competition
Nearly $10 billion worth of biotech drugs will go off patent in the next two years. Low cost versions of biotech drugs will soon be an important sector within the pharma market. The European Commission recently granted final approval for Novartis' generics business Sandoz to launch 'biosimilar' epoetin alfa, a generic version of Amgen's very popular Epogen.

Because biologics are derived from living things, it is not easy to make exact copies as is the case for chemical-based therapies. Biosimilars are close approximations of original medicines, and their regulation requires a new framework separate from that for traditional generics. Europe is ahead of the U.S. in developing legislation for handling biogeneric approvals.

The new competition will force biotech companies to change their approaches to product development, marketing and regulatory submissions as pressure from generics manufacturers will be high. Leading Indian generics firms such as Dr. Reddy's Laboratories, Wockhardt, Biocon and Panacea Biotech are already preparing to take advantage of the opportunity.
 

 



 

 
Commodity Chemical Prices Rising in Asia
Methanol supplies are tight in Asia following a fire on four barges at the Yangtze River transshipment hub. The key port remained closed for some time. Prices for Methanol are highest in China as demand remains strong. Global shortages due to both planned and unplanned outages have resulted in price hikes around the world. Asian prices are up as much as 20 percent, but are still lower than those in Europe and the U.S. With high inventories of previously importer material, Indian importers are re-exporting Methanol to take advantage of the large price differential. Even so, spot material is difficult to find.

Butadiene spot prices in Asia rose dramatically in response to tight supplies. Planned maintenance shutdowns were implemented at a time when other manufacturers were experiencing production problems, leading to limited availability.

Acrylonitrile (ACN) prices in China have hit new highs in response to a shortage of supply resulting from unexpected plant outages and maintenance turnarounds across the globe. Downstream Acrylic fiber producers in China have cut operating rates and may shut down operations completely in response to the negative impact on their profit margins.

High feedstock costs (Acetone and Naphtha) and tight supplies are also driving up Methyl isobutyl ketone (MIBK) prices in Asia.

Styrene monomer (SM) prices in China are also rising in response to strong demand and short supplies. Toluene prices in Asia hit a six-week high in mid-September as a result of high crude oil prices. Many traders do not expect the hikes to last because demand remains stable to weak.
 

 



 
Phenol Markets Unsettled
Lack of demand from the downstream Phenolic resins sector has led to price declines for Phenol in China. Prices for both domestic and imported material have dropped and are expected to fall further. Meanwhile, India began collecting anti-dumping duties on Phenol imports from the European Union, Singapore, and South Africa. The government is also investigating imports from South Korea, Taiwan and the U.S. Domestic prices in India rose in response to the increased duties on imported material.

 



 

 
Europe Faces Tightness in Several Intermediates
Rising prices and tighter supplies of Monoethylene glycol (MEG) could impact downstream Polyester and antifreeze customers in Europe. Availability is short due to both planned and unplanned European shutdowns and lack of material for import. There is very little spot material available, and record high prices are expected in October. Diethylene glycol (DEG) spot prices are also climbing due to low producer stocks and limit availability of import material.

Tightness in Ethylene oxide due to both planned and unplanned outages is expected to lead to price hikes, which will in turn affect the spot markets for Butyl glycol ether (BG) and Butyl di-butyl glycol ether (BDG). Polyethylene terephthalate (PET) supplies are expected to dimi