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Leading Pharmas Face
Years of Patent Expirations
Following the expected large number of patent
expirations that will take place by 2010, a second
set of drugs will come off patent between 2010 and
2014. Eli Lilly and Pfizer will be hardest hit by
this second wave of expirations. Five of Lilly's
drugs representing about 60 percent of the company's
pharma revenues will be affected. Pfizer could lose
as much as $18 billion (Euro 12.2 billion) as its
key drugs Lipitor, Viagra and Celebrex, among
others, lose their patent protection. Pfizer has
also struggled with the development of new drugs,
having pulled its anti-diabetes therapy Exubera from
the market. IMS Health predicts that the growth of
the pharma industry will decline in 2008 to 5 to 6
percent from the 2007 level of 6 to 7 percent.
Generics, on the other hand, will see strong growth
by 14 to 15 percent in 2007 alone.
While Pfizer does not have a strong pipeline to
counteract its losses due to patent expirations, it
is looking to cut costs by moving R&D efforts to
Asia and increasing outsourcing in the region. The
company may outsource as much as 30 percent of its
manufacturing in Asia, up from the current level of
15 percent. Pfizer will close several research sites
and two manufacturing facilities in Brooklyn, NY and
Omaha, NE, plus sell a third production site in
Feucht, Germany.
AstraZeneca also announced that is will begin
shifting operations to Asia and accelerate
activities in the Japanese market. |
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Dow Makes
Cuts
To
achieve annual savings of about $180
million, Dow Chemical will close plants and
eliminate as many as 1,000 jobs. Facilities
likely to be shut down include an
agrochemicals intermediates plant in
Lautebourg, France, Hydroxymethyl cellulose
plant in Aratu, Brazil, a Styrene plant in
Camaçari, Brazil and a Union Carbide
Polypropylene plant in St Charles,
Louisiana. R&D activities at a Union Carbide
site in South Charleston, W.Va. will also be
reduced significantly. In addition, the
company will exit the automotive sealants
business in North America, Asia Pacific and
Latin America. Further decisions could be
pending with other commodities businesses.
These actions will make capital available
for investment in projects in Asia and the
Middle East. Dow Chemical recently announced
that it will invest in an $11 billion joint
venture with Petrochemical Industries Co. in
order to gain access to cheaper feedstocks.
Dow will sell to PIC for $9.5 billion a 50
percent share in five of its global
businesses that are worth about $19 billion.
The JV will be headquartered in the United
States, will operate as a separate company
(its name has not been chosen yet) and will
produce Polyethylene, Ethylenamines,
Ethanolamines, Polypropylene and
Polycarbonate. The two companies already
have other joint ventures and have been
working together for 10 years. The new joint
enterprise will mean that Dow will have
projects integrated from feedstocks to
derivatives. |
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PPG has
Trouble with Sale of Auto Glass Business
PPG's
$500 million sale of its automotive glass
businesses to investment firm Platinum
Equity has run into trouble. Platinum has
accused PPG of inflating the value of its
businesses and filed a lawsuit seeking to
abandon the deal and alleging that PPG
provided false revenue projections,
understated pension liabilities and
obligations and deferred several million
dollars of maintenance expenditures.
Platinum says that if it had known this
information it would have lowered its
purchase price or not entered into a
purchase agreement. The company is seeking
from PPG the costs and expenses incurred in
connection with the transaction, lost
opportunity costs and punitive damages.
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Reorganization at BASF

Effective Jan. 1, 2008, BASF will operate
with six business segments rather than five.
The segments include chemicals, plastics,
functional solutions, performance products,
agricultural solutions, and oil and gas. The
new functional solutions unit will
incorporate the catalysts, construction
chemicals and coatings divisions and will
largely serve the automotive and
construction industries. Performance
products will include the newly created care
chemicals division (fine chemicals plus
detergents and cleaners) plus acrylics and
dispersions, which previously was the
functional polymers business. The
performance chemicals segment will target
the oil and refinery, coatings and plastics
and leather and textile industries. BASF
will divest its styrenics business.
According to the company, the change will
enable BASF to be faster to market, closer
to customers, increase efficiency and ensure
greater cyclical resilience. |
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China Gets
Tougher on Exports
After
cutting export tax rebates for over 2,000
products in 2007, China may apply further
pressure in 2008 on the export of light
industrial products such as plastics and
electrical appliances. The 2007 cuts,
however, do not appear to have affected the
level of exports, which grew by 20 percent
in November as compared to the same month in
2006. In general producers passed on price
increases that were accepted by buyers who
could not find alternative sources for these
materials.
The Chinese government might introduce taxes
on energy-intensive and environmentally
unfriendly products in addition to
maintaining the rebate cuts to further
reduce exports. The central government will
also release regulations on emissions and
safety performance for manufacturers
involved in the Chlor-alkali production
chain, which should create barriers to entry
into this industry. |
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Firms Fined
by South Korea for Polyethylene Price Fixing
Hanwha
Chemical, LG Chem, SK Energy, Samsung
General Chemicals, Seetec and Samsung Total
Petrochemicals received fines totaling $58.1
million (W 54.1 million) by South Korea's
Fair Trade Commission for fixing prices of
low density Polyethylene (LDPE) and linear
LDPE (LLDPE). The case is the second in
2007. The government previously fined
companies a total of $112.7 million (W 105
million) for forming domestic high density
PE (HDPE) and polypropylene (PP) cartels for
the past 12 years. The agency may expand its
investing to Styrene monomer as well.
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New Price
Fixing Fines for European Companies
Denka,
DuPont, Dow Chemical, ENI and Tosoh have
been fined a total of $357 million (Europe
243.2 million) by the European Commission
(EC) for conspiring to fix prices of
Chloroprene rubber from at least 1993 to
2002. Bayer's Euro 201 million fine was
rescinded because the company was the first
to come forward with information.
In a separate case, the EC increased BASF's
fine for its part in a Choline chloride
cartel by $79,294 (Euro 54,000). BASF, Akzo
Nobel and UCB were initially fined a total
of Euro 66 million in 2004 for price-fixing
activities from June 1992 to April 1994.
BASF and UCB appealed the decision. In
response to the appeal, the court raised
BASF's fine but lowered UCB's amount by 90
percent, since UCB reported the European
activities of the cartel. |
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Potential
for Growth Abroad but Tough Times at Home
for U.S. Chemical Companies in 2008
Restrictions
on natural gas and rising crude oil prices
will have a negative impact on the United
States chemical industry in 2008. The energy
bill passed by Congress in late 2007
strongly pushes for increased biofuels and
will create a level of demand for natural
gas greater than current supplies.
Additionally, climate change legislation
that is expected to be adopted in 2008 will
likely force many chemical producers and
utilities to switch from coal to natural
gas, further heightening demand.
American chemical companies will be facing
this energy and raw material crisis at a
time when the country may be facing a
recession. The continuing decline in the
housing market will affect many segments of
the chemical industry. Automobile
production, while not expected to drop
further, is predicted to remain at the low
levels seen in 2008. Manufacturing sectors
not connected to housing or automobiles are
the only areas of the U.S. economy that are
expected to perform well in 2008.
Given the situation at home, many commodity
chemical producers in the United States are
looking to exports to maintain
profitability. The weak dollar is making
their products much more competitive in the
global chemical marketplace. Growing demand
overseas is also a favorable factor, as is
access to competitively priced feedstocks.
Outsourcing of pharmaceutical production
will continue, however. |
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New Deals in
Contract Manufacturing
Several transactions have taken place
recently in the world of contract
manufacturing. Cambridge Major Laboratories
acquired Chemshop, a supplier of active
pharmaceutical ingredients (API) development
services. Cambridge will expand reactor
capacity and increase the laboratory
capabilities at the European site, which has
been renamed Cambridge Major Laboratories
Europe. PPG Industries completed the $65
million sale of its fine chemicals business
to ZaCh Systems, a subsidiary of Zambon
Company. PPG sold the business as part of
its strategy to focus on coatings and
specialty products.
Aptuit purchased the chemical development
business of Evotek for about $64.57 million
(Euro 44.36 million) to expand its
development services. Evotek sold the
business in order to focus on its high-end
research capabilities. Isochem sold its
NeoMPS peptides business to PolyPeptide
Laboratories Group for an undisclosed
amount. Finally, ownership of Vertellus
Specialties changed from Arsenal Capital
Partners to Wind Point Partners. Arsenal
formed Vertellus in 2006 by combining the
operations of Reilly Industries and
Rutherford Chemicals. Richard Preziotti, a
former executive at Honeywell, will take the
position of CEO at Vertellus. |
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Big Pharma
Reductions Will Pay Off
More than 30,000 job cuts have been
announced by big pharma companies in 2007.
Analysts predict that these actions, while
painful, will benefit these key players in
the future. Novartis recently joined Eli
Lilly, Pfizer, GlaxoSmithKline,
Bristol-Myers Squibb and several others with
announcements of significant reductions in
personnel and plans for reorganizing
operations. In the end, according to
analysts, leaner businesses that have
shifted some operations overseas will be
better suited to compete with low-cost
producers in emerging markets. |
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Spotlight on
Biopharma
Major pharma companies are investing heavily
in biopharma firms as they look to biotech
for strong profits. Novartis AG has signed a
$1 billion R&D contract with MorphoSys AG
for the development of antibody-based
therapies. Merck & Co. agreed to pay $170
million to Addex Pharmaceuticals to develop
a treatment for Parkinson's disease and
Sanofi-Aventis will invest as much as $810
million in Regeneron Pharmaceuticals for
antibody-based research.
Many leading drugs on the market today are
biologics, such as Herceptin (Roche
Holding), Remicade (Johnson & Johnson) and
Humira (Abbot Labs). Sales of
biopharmaceuticals in the United States grew
20 percent in 2006 to reach $40.3 billion,
according to IMS Health. Biologics are also
attractive because they do not face generic
competition, at least in the United States,
where the FDA has yet to establish a
regulatory protocol.
At the same time, many biopharma firms are
anticipating decisions from the FDA that
will determine their future. Approval
decisions are expected in December 2007 for
drugs from Neurocrine BioSciences, BioMarin
and Pharmacyclics, while Biogen Idec,
Cardiome, Discovery Labs, Elan, Genentech,
Indevus Pharmaceuticals and Johnson &
Johnson will be waiting for decisions in
2008. Other companies that have yet to
formally submit drugs for approval but are
expected to do so include Advanced Life
Sciences, Genitope, ImClone Systems and
Medarex. |
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Deal Between
Nufarm and ChemChina Cancelled
A
consortium of buyers led by ChemChina was
unable to formalize a proposal for the $2.63
billion takeover of Nufarm before the
deadline for expiration of the agreement. As
a result, talks between the two companies
have been halted. ChemChina, Blackstone and
Fox Paine Management had signed an
exclusivity agreement to buy Nufarm, but
Nufarm is no longer obligated to the group
now that the deed has expired. Nufarm
indicated that it is interested in speaking
with other potential bidders.
Separately, ChemChina also failed to come to
an agreement with the parent company of
Shandong Haihua about cooperation between
the two companies. |
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Fertilizer
Industry Facing Shortages of Key Materials
Phosphoric acid, a key raw material in the
production of phosphate fertilizers, will be
in tight supply through 2010, according to
the International Fertilizer Industry
Association. Additional capacity is being
added, but it will not be on-stream until
2011. Much of the material will be used for
domestic downstream applications in China
and Saudi Arabia, though, and most of the
capacity targeted for export is already
under contract. Urea supplies are also
tightening, as new production plants around
the world are experiencing delays. Industry
operating rates are currently at 90 percent.
Even if planned projects do come on-stream
on time, there will not be a surplus until
2010. Most urea is used as fertilizer, but
non-fertilizer applications are expected to
grow rapidly over the next few years, adding
to the need for increased capacity.
Prices for many fertilizers hit record highs
in 2007 as a result of an increased demand
for food at a time of low grain stocks.
Increased demand for crops used for biofuels
production and resulting high crop prices
also contributed to the rise in fertilizer
prices. These conditions continue to be
factors in 2008.
The shortness in the Phosphoric acid market
is impacting the Indian farm sector.
Domestic phosphate fertilizer producers are
not able to import the necessary quantities
of Phosphoric acid, resulting in idle
capacity. Prices for 2008 contracts are
significantly higher than 2007 levels and
are expected to climb further. India is also
the world's largest importer of Diammonium
phosphate (DAP) and Urea. |
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China Market
Cooling Off?
Key
industry players in China predict that
demand for petrochemicals in China will slow
down in 2008 as government controls and high
energy and raw material costs take their
toll. The Chinese government has implemented
both financial controls and safety
regulations that are affecting the industry
at a time when crude oil costs are rising
rapidly. Further actions may include
additional tightening of credit and removal
of remaining export subsidies. Controls in
downstream markets such as the construction
industry are also having an impact.
Contraction in demand for Ethylene and
derivatives, as well as many of the major
polymer markets, is expected. |
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Middle East
Center of Chemical Activity
Ready
access to low-cost feedstocks is enabling
the Middle East to establish itself rapidly
as a major exporter of petrochemicals. The
level of building is placing significant
pressure on engineering firms and resources,
including skilled labor, materials and
construction equipment, resulting in the
delay of several projects. Rising feedstock
costs and constraints on some raw materials
(Ethane in particular) are also becoming
growing concerns.
Despite these difficulties, analysts predict
that producers in the Middle East will
become true global players, reaching
customers around the world and offering more
than Ethane-based derivatives. Successful
companies will be from global partnerships.
The diversity of projects (commodity and
specialty chemicals) and careful control of
costs will also be critical for companies
looking to take a top position in the
worldwide chemicals marketplace.
Companies building facilities include Kuwait
Olefins Co. (TKOC), a joint venture project
between Petrochemical Industries Co. of
Kuwait and Dow Chemical; Ras Tanura, a Dow
Chemical and Saudi Aramco project; Jam
Petrochemical Co. (JPC); Rabigh Refining &
Petrochemical project, a joint venture
between state-owned Saudi Aramco and
Sumitomo Chemical; Eastern Petrochemical (Sharq);
and Borouge, a joint venture between
Borealis and ADNOC.
Most of the projects are expected to be
on-stream by 2012. Many wonder about the
impact this increase in capacity will have
on the marketplace, as it will occur at the
same time that many new Asian plants will be
starting operations. Oversupply in Ethylene
is of particular concern. |
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Questionable
2008 for Olefins
High feedstock costs are likely to plaque
olefins producers around the world in 2008.
High crude oil prices are squeezing margins
for producer in the United States, Europe
and Asia. Some producers in Asia are
considering reducing exports to save costs,
which could reduce spot availability.
Supplies will be further tightened in the
region, with a significant number of
maintenance turnarounds scheduled in Japan
in 2008. Growing demand could place further
strain on the market. Traders are hopeful
that large production capacity in the Middle
East will provide access to material.
European producers are concerned about the
access that Asian and Middle Eastern
producers have to lower cost Ethylene. They
also must hope that downstream polymer
markets will accept the record high olefins
prices necessary for maintaining even slim
margins. In the United States, olefin
producers also face tight suppliers and high
crude oil costs. Strong demand for
derivatives and increased imports will
continue in 2008. There are also a number of
planned shutdowns scheduled in the Unites
States in 2008. |
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