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Dishman Netherlands B.V. Opens New High-Tech
Laboratory
Dishman Netherlands
B.V. recently opened its new high containment cGMP
laboratory. Among the important attendees of the
event were Mr. Jay Vyas, Chairman and owner of the
Indian Dishman Group as well as representatives from
such multinationals as Pfizer and Solvay. Support
for the project was provided by Van Spanje, Techtron,
Cleangrad, de Van Looy Group, Termovent and Waldner
Benelux.
The decision to build the facility is in keeping
with the company’s commitment to develop new Vitamin
D analogues and highly potent APIs. In addition to
increasing its current product portfolio, Dishman’s
strategy involves expanding its business
opportunities with new business partners in the
areas of product development as well as contract
research and manufacturing.
Located in Veenendaal, The Netherlands, the new
laboratory consists of 6 dedicated clean rooms with
a scale of operation of up to 1 kg in addition to
all standard laboratory facilities. An FDA
compliance
audit is expected in H1 of 2010.
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“Great
ability develops and reveals itself
increasingly with every new assignment.”
Baltasar Gracian
“A positive attitude may not solve all your
problems, but it will annoy enough people to
make it worth the effort. “
Herm Albright
“In the business world, the rearview mirror
is always clearer than the windshield. “
Warren Buffett
“Only I can change my life. No one can do it
for me.”
Carol Burnett
“Change your thoughts and you change your
world.”
Norman Vincent Peale
“The incompetent with nothing to do can
still make a mess of it.”
Laurence J. Peter
“The secret of joy in work is contained in
one word - excellence. To know how to do
something well is to enjoy it.”
Pearl Buck
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How Do X-Rays Work?
German physicist Wilhelm Roentgen discovered
x-rays in 1865. Roentgen had enclosed a
glass tube inside of a black paper box.
Wiring, similar to that of a light bulb, ran
inside of the tube and allowed for
electrical currents to accumulate within it.
An induction coil enabled electrical current
to travel into the tube, with the result
being a faint green-colored light which
spread across the room. While the rays were
not visible to the naked eye, they
penetrated materials like wood and metal.
After reproducing these findings, Roentgen’s
hand came in contact with the tube one day.
The shadows he saw of his hand and fingers
showed darker shadows representing the
bones, with the shadow moving as his hand
moved. A screen across the room was coated
with a chemical. The shadow hit the screen
and the end result was the first x-ray
picture. Within a year of the discovery, the
new technology was being used for imaging
the human body.
Unlike visible light, x-rays penetrate
through materials of light atoms, including
those which compose the human body. While
they pass through human flesh, which is
composed primarily of water, heavier atoms
like metal absorb them. X-rays are produced
when a beam of high energy electrons
collides with a metal target. Low energy
rays are blocked by a filter by the x-ray
source while the high energy rays pass
through a patient towards a sheet of film. A
shadow of the inside of the body is
produced. A second sheet of film is used to
prevent scattered x-rays from fogging the
picture.
The various tissues that make up the human
body absorb x-rays to different extents and
only three tissues are sufficiently
different from each other in terms of x-ray
absorption to show up on an x-ray film.
Calcium in bones is considered a type of
metal, which offer high absorption and show
up white, while soft tissues, muscle, heart
and blood vessels appear in similar shades
of grey. Air, which may appear in areas such
as the lungs, appears black on an x-ray.
Because many of the soft tissues tend to
look alike on an x-ray image, a variety of
artificial contrast materials are often
used. A thick suspension of barium sulphate
can be introduced to coat the desired areas.
Being the salt of a heavy metal, it absorbs
the x-rays quite well, making the areas it
has coated appear much whiter. Other media,
usually containing iodine can also be
introduced to the body and are used to show
greater contrast. Angiography, which
involves injecting the substance directly
into an artery, will reveal the vessel, and
any organ (or tumor) which it supplies. From
this type of investigation, the
sub-specialty of interventional radiology
developed, transforming radiology from a
purely diagnostic specialty to one where
radiologists can also treat patients. In
many areas, radiological techniques have
replaced major surgical procedures when
performed under local anesthetic with or
without light sedation.
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Chemical Information Services Adds Becker
Products to Portfolio

Chemical Information Services
has partnered with Becker &
Associates to add a new line of
offerings to its product portfolio. Becker &
Associates’ database products provide
essential scientific, technological,
commercial and patent data gathered to
fulfill the information needs of drug
development and manufacturing professionals.
Nearly 3 gigabytes of complex expert
information is edited in state of the art
proprietary programs to enable easy and
instant access to the most complicated data.
Text and structure are compressed in
original SQL databases, available in CD-ROM
and on-line versions. The Becker products
offered include the following:
• B.I.C.-3000 – Becker Intermediates
Catalog
• F.G.D. – Future Generics Database
• P.P.D – Pesticide Production
Database
• P.I.D. – Pharmaceutical
Intermediates Database
• Conceptus – Combination of B.I.C
and P.I.D Databases
For additional information on any of our
products, please visit
www.chemicalinfo.com.

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Praxair to Build and Operate New Hydrogen &
Nitrogen System in India
Praxair,
Inc. was recently awarded a major order from
the Indian Oil Corporation Ltd. for the
long-term supply of hydrogen and nitrogen
gases to its new 300,000 barrels per day
greenfield oil refinery. Praxair will build
the new facility at Paradip, Orissa on the
eastern coast of India. It will consist of a
90 million standard cubic feet per day
hydrogen plant and a 500 tons per day
nitrogen plant, with start-ups scheduled for
the first quarter of 2012. The new refinery
is designed to process lower-cost
high-sulfur and heavy crude oil.
The hydrogen supplied will be used by Indian
Oil for the processing of various crude oil
slates as well as for the production of low
sulfur, clean fuels. Indian Oil is
augmenting its existing refining ability by
establishing the Paradip refinery, with the
capacity of 300,000 barrels per day at a
cost of about $6.5 billion. The endeavor
will help meet the current growing energy
demands of the Indian domestic market and
the needs of the South East Asian export
market expected in the near future.
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Lapolla Industries Signs Agreement with
Exova
Houston, Texas-based Lapolla Industries,
Inc. has contracted with nationally
accredited Canadian testing laboratory Evoxa,
to conduct the In-Field Quality Assurance
Program for the FL-2000 (FoamLOK),
Evaluation listing CCMC 13414-L.
Lapolla Industries, Inc. is a leading
manufacturer and supplier of spray
polyurethane foam for insulation and
coatings targeting residential and
commercial applications in the building
envelope construction industries.
International organization Evoxa serves
local markets in a wide range of industries
and specializes in testing, engineering
technology, certification, calibration and
advising and consulting. The company was
recently added to the short list of
qualified In-Field Inspection Firms
recognized by CCMC for the Canadian markets.
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AlumiFuel
Power, Inc.’s Technology Generates Interest
at Naval Energy Forum
AlumiFuel
Power, Inc. (“API”), an early production
stage hydrogen generation company, showcased
its technology at the Naval Energy Forum
recently held in McLean, Virginia. API is a
Pennsylvania-based, wholly-owned operating
subsidiary of AlumiFuel Power Corporation.
The Naval Energy Forum was a major
conference conducted within the Department
of Defense. Attended by over 700 people from
government and industry, it featured the key
themes of energy security, energy
efficiency, environmental stewardship, and
energy science and technology (S&T).
Interest in API’s technology for a variety
of target applications included undersea
vehicle propulsion, feeding fuel cells for
on-demand remote power generation, lift gas
for special purpose naval balloons, hydrogen
boost for diesel engines, flameless heaters
for military rations (Meals Ready to Eat, or
MREs), and the combustion source for a Navy
“hydrogen gun.” The company also submitted
three white papers at the conference.
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Sigma-Aldrich Launches Facebook® Application
Sigma-Aldrich
has launched a unique life science-focused
application for the social media site,
Facebook®. Entitled ‘What’s Your Favorite
Gene?, the application was developed and
marketed by Sigma® Life Science. It provides
a platform enabling scientists and
researchers to network with each other,
facilitating discussions among users. In
addition, it allows researchers to post and
share gene information using gene details,
associated pathways and interactors from
Sigma-Aldrich’s online search platform,
'Your Favorite Gene powered by Ingenuity'.
The application is designed to encourage
scientists to become “fans” of their
favorite genes and then connect and network
with colleagues to share their experiences
while simultaneously building their own
scientific profile.
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American Pacific Appoints Two New Directors
Custom manufacturer of fine chemicals,
specialty chemicals and propulsion products
American Pacific Corporation (AMPAC)
recently announced the election of Barbara
Smith Campbell and William F. Readdy to
serve on its Board of Directors. The
addition increased the size of the company’s
board to ten directors.
Ms. Campbell is President of Consensus, LLC,
a company which she founded in 2005. Prior
to starting Consensus, she served as a
member of the Nevada Tax Commission for 5
consecutive terms and as the Commission's
Chairman from 1996 to 2005. She currently
serves as a Trustee for the Donald W.
Reynolds Foundation and Advisory Board
Member of Amerco, parent company of U-Haul
International.
In 2005, Mr. Readdy established Discovery
Partners International LLC, a consulting
firm to provide strategic planning, risk
management, safety and emerging technology
solutions to aerospace and high-tech
industries. Prior to that, he served as
NASA’s associate administrator for space
operations and chaired the Administration’s
Space Flight Leadership Council until 2005.

Rexam Announces New Chief Executive
Graham Chipchase has been chosen to succeed Leslie
Van de Walle as Chief Executive Officer of
global consumer packaging company, Rexam
PLC. The appointment will be effective
January 1, 2010, when Van de Walle retires
to pursue other non-executive interests.
Chipchase has been Group Director Plastic
Packaging since July 2005 and joined the
Rexam Board as Group Finance Director in
February 2003.

BIA Appoints Director in Scotland
The BioIndustry Association (BIA) has
appointed Scott Johnstone as Director in
Scotland. Based in the Edinburgh office, he
will lead the organization’s work with the
biotech community in Scotland, including
both the Scottish Parliament and BIA
members.
Scott will work part-time for the BIA while
retaining his existing part-time position as
Chief Executive Officer of Antoxis Ltd., the
company founded by him in 2005. In addition,
he will continue with his duties as Life
Science Business Advisor and Technology
Entrepreneur for the Scottish Enterprise
Proof of Concept program.

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Clairiant Optimizes Global Network
In an effort
to address overcapacities and reduce costs,
specialty chemical leader Clariant plans to
further optimize its global production
network. The company’s ‘Global Asset Network
Optimization’ (GANO) project is composed of
a detailed evaluation of its entire
production network and is part of Clariant’s
broader restructuring program. The program
focuses on closing the gap the company has
realized when compared to its peers on
several key performance factors. GANO
addresses both structural deficits in the
production network and long term
overcapacity issues.
The project involves initial proposals to
close various sites. The sites nominated for
closure are Huningue, France; Pontypridd,
UK; CIVAC, Cuernavaca in Mexico; and parts
of two plants at Clariant sites in Germany,
at Gendorf and Frankfurt. An evaluation of
all strategic options for the facility in
Onsan, South Korea will also be initiated.
Approximately 570 jobs worldwide will be
affected by the proposals. Completion and
full implementation of the initial proposals
is expected to occur between 2011 and 2013.
The company feels that the restructuring
will significantly improve the efficiency of
its production network while increasing its
competitiveness.
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Mitsubishi Rayon to Stop Production of
Silpalon
Due to decreased sales in Japan, Mitsubishi
Rayon has pulled out of the Silpalon acrylic
filament yarn business. In addition to
decreased sales, manufacturers are switching
to alternative fibers due to falling textile
prices, therefore sales volumes in China and
South Korea have fallen.
While Mitsubishi Rayon’s subsidiary
Mitsubishi Rayon Textile, located in Otake,
Hiroshima, normally produces 2,200
tonnes/year of acrylic filament, production
fell to only 1,000 tonnes/year last year.
End of production is scheduled for March
2010.
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Air Products Completes Sale of Polyurethane
Pre-Polymers Business 
Air Products has
finalized the sale of the assets of its
polyurethane pre-polymers business, marketed
under the Airthane® and Versathane® trade
names, to COIM USA Inc., a fully owned
subsidiary of global polyurethane chemicals
producer COIM SpA. While terms of the
agreement are not being disclosed, the sale
included Air Product’s Paulsboro, New Jersey
manufacturing facility.
Air Products will continue to
focus on the global growth of its Dabco® and
Polycat® polyurethane catalysts and
surfactants, Versalink(TM) curatives and
their new Innovathane® and Ancarez® ISO
products for the Polyurea coatings and
construction markets.
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Biota Completes Two Drug Discovery
Acquisitions
Biota Holdings Limited has announced it has
completed two acquisitions.
The assets and drug development programs of
MaxThera, Inc., an antibacterial drug
discovery company in Boston, Massachusetts,
are being acquired subject to conditions
Biota expects to meet in the near future.
MaxThera has developed a lead program which
targets inhibitors of an essential bacterial
enzyme in the Coenzyme-A biosynthetic
pathway, which is responsible for metabolic
processes in bacteria. This acquisition will
expand Biota’s drugs in development beyond
antivirals into other anti-infectives.
MaxThera’s assets will be acquired for $1.2
million in cash and $30,000 in Biota shares.
The assets and programs of Prolysis Limited,
an antibacterial drug discovery company in
Oxford, England are also being acquired by
Biota. Prolysis is developing two projects
focusing on multiple drug resistant
infections and new antibiotics; the Gyrase
program and a Cell Division Inhibitor (CDI).
All staff and main activities at its
laboratory facilities in Oxford will be
retained by Biota. Prolysis’ assets and
programs will be acquired for $10.8 million
in Biota shares, 60% of which will be
subject to a 12-month escrow period. Also
included in the agreement is the ability to
receive up to 15% share in milestone and
royalties earned after commercialization.
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Solutia’s Therminol® 55 Selected by IMTT
Solutia
Inc. announced that International Matex Tank
Terminals (IMTT) has chosen Solutia’s
Therminol® 55 heat transfer fluid for its
2009 tank terminal expansion project.
IMTT, a world-class provider of bulk liquid
handling services, has used Therminol® at
its St. Rose, Louisiana plant for over 30
years. This is the largest expansion of the
50 year old company.
Therminol® 55 provides indirect heat to
storage tanks to prevent high melting point
compounds, such as asphalt and diesel fuel,
from solidifying. Unlike conventional
mineral oils, Solutia’s Therminol® 55 is
resistant to oxidation and has outstanding
thermal stability.
Solutia manufactures its heat transfer fluid
on four continents, offering a worldwide
product supply..
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Abbott Acquires Global Rights to PanGenetics’
PG110
Expanding its pain
care portfolio, Abbott has announced its
acquisition of global rights to PanGenetics
BV’s PG110 humanized antibody to Nerve
Growth Factor (NGF). Delivering long-lasting
analgesia without the potential for
dependence and abuse, PG110 is a biologic in
Phase I clinical trial for the treatment of
chronic pain.
Currently, pain signals transferred by the
central nervous system are blocked with
treatments such as NSAIDS, opioids, Cox-2
inhibitors, and other analgesics. However,
besides potential for addiction and abuse,
tolerability and safety issues arise. If
Phase I trials of PG110 are successful,
other pain states will be studied, including
cancer pain, lower back pain, and diabetic
neuropathic pain.
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Novarits’ Agriflu Approved by FDA
The U.S.
Food and Drug Administration recently
approved Agriflu for the prevention of
disease caused by influenza virus subtypes A
and B.
Manufactured in Siena, Italy by Novartis
Vaccines and Diagnostics, Agriflu was placed
on the FDA’s accelerated approval pathway
making it available sooner. Novartis must
continue to demonstrate, as part of the
accelerated approval process, that Agriflu
is able to prevent seasonal influenza by
inducing levels of antibodies in the blood.
It is administered as a single injection and
is available to people ages 18 years and
older. The company also manufactures
Fluvirin for use in the United States.
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DuPont and Dow AgroSciences Commit to
Cross-Licensing Deal
Dow
AgroSciences and DuPont have entered into a
cross-licensing agreement that will offer
farmers additional weed control options for
soybean production. Dow AgroSciences, a
wholly-owned subsidiary of the Dow Chemical
Company, is licensing its herbicide tolerant
trait technology to DuPont business Pioneer
Hi-Bred. In turn, Pioneer is granting Dow
AgroSciences its proprietary Optimum® GAT®
trait for soybeans.
The new technology being developed will be
based on 2,4-Dichlorophenoxy acetic acid
technology and will provide improved control
of glyphosate-resistant weeds, as well as
broadleaf weeds like pigweeds and morning
glory, ragweed, and velvetleaf.
Commercialization is expected in the next
decade pending approval by U.S. regulatory
agencies this year. Dow AgroSciences is
based in Indianapolis, Indiana, U.S.A.
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Syngenta Corn Traits Receive Approval in
Brazil
Following
the approval by the National Biosafety
Committee and a 30-day clearance period,
Syngenta’s genetically modified corn traits
- M1R162 and Bt11xGA21 - have been approved
for cultivation in Brazil. These advanced
technologies will enable growers to increase
global competitiveness and efficiency
through higher grain quality, increased
productivity, and reduced production costs.
Bt11xGA21 offers combined insect resistance
and herbicide tolerance, while the
effectiveness and broad spectrum of M1R162
control the fall army worm. Together, these
approvals strengthen Syngenta’s portfolio
and reinforce its position in innovation and
technology. The company employs more than
24,000 in over 90 countries.
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Braskem/Idesa Form Ethylene Joint Venture
Braskem and Idesa are partnering to form a
petrochemical project in Mexico after
winning Pemex Gás’ auction for the
acquisition of raw materials.
Natural gas will be supplied for 20 years to
be used in a cracker with an ethylene
capacity of 1 million tons per year. Three
polymerization units will use the ethylene
to produce 450,000 tons of HDPE and 200,000
tons of LDPE per year.
Braskem (Brazil) and Idesa (Mexico) will
form a joint venture in the Coatzacoalcos
Petrochemical Complex in Veracruz, Mexico,
supplying the domestic market, which
currently imports polyethylene. The new
complex is expected to provide competitive
access to the raw materials needed to
produce HDPE and LDPE. Operations are
projected to begin in 2015.
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AkzoNobel Acquires Powder Coatings
Activities from Dow
AkzoNobel will
acquire Dow Chemical Company’s powder
coatings activities, expanding its portfolio
of sustainable technologies and allowing it
to further penetrate industrial coatings
segments in the U.S. Powder coatings contain
no solvents, offering a sustainable
alternative to liquid coatings, with
application efficiency levels of 99%. This
deal will add thermoplastic and MDF
capabilities to AkzoNobel’s expertise,
delivering improved operational efficiency
and allowing better service to worldwide
customers.
The powder coatings activities of Rohm &
Haas, located in the U.S., Europe, and
China, were purchased by Dow earlier this
year. The segment currently employs around
700 people and achieves global sales of
several hundred million dollars.
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CalciRC100S™ Launched by CalciTech
A new product has been launched by CalciTech
Ltd. for use as a filler in plastics.
CalciRC100S™ promises to bring benefits over
conventional calcium carbonates as well as
improved sustainability for plastics
producers.
In PVC profiles, trials have such benefits
as higher gloss and toughness, thermal
stability and improved whiteness, lower
costs, and consistent high quality. Less
polymer resin is used because CalciRC100S™
can be used with higher loading levels.
Additionally, Synthetic Calcium Carbonate (SCC)
is manufactured using CalciTech’s process of
utilizing waste lime and effluent carbon
dioxide (CO2), thereby capturing the CO2
rather than relying on unsustainable freshly
mined materials.
CalciTech operates out of Geneva,
Switzerland.
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A.Schulman Receives SPE Recognition for
AgriPlas™
A.
Schulman, Inc. announced that one of its
products has received innovation recognition
from the Society of Plastics Engineers’ (SPE)
Automotive Division.
Its AgriPlas™ wheat straw fiber bio-filler
was a Blue Ribbon Finalist for an
Environmental Innovation Award. Featured in
Ford’s new Flex crossover vehicle, AgriPlas™
is an application for an injection-molded
storage bin and inner lid for the interior
of the Ford Flex.
AgriPlas™ is polypropylene containing wheat
straw fiber – a by-product of harvesting
wheat. This “bio-filler” offers advantages
talc- and/or glass-filled polypropylene do
not, such as weight savings of 10%, less
energy used in manufacturing, increased
dimensional stability, and lower carbon
footprint.
Currently, A. Schulman supplies
high-performance plastic compounds and
resins for use in consumer, automotive,
industrial, and packaging applications. They
are exploring other uses for the AgriPlas™
wheat straw fiber in non-automotive
applications, as well as additional
automotive interior and under-the-hood
applications.
Headquartered in Akron, Ohio, the company
employs about 2,000 people at 16
manufacturing facilities in North America,
Europe, and Asia.
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Symrise Expands Portfolio
Flavoring
and fragrance manufacturer Symrise has
expanded its portfolio with a new Consumer
Health business unit for food supplements,
health care and specialty products. In
addition to satisfying the growing demand
for health-oriented foods, the expansion
increases the company’s competency and
improves its competitive advantage. The new
Consumer Health unit will focus on
functional ingredients for modern food
supplements and offer flavor solutions for
health products. The company’s Consumer
Health team will be lead by Dirk Bennwitz
and will be the driving force in Symrise’s
health and nutrition strategy. The business
unit will be supported by the Symrise
Competence Center for Health & Nutrition,
which works as an independent entity for all
four of the company’s business units –
Beverages, Savory, Sweet and Consumer
Health. The Competence Center provides the
unit’s market and consumer data, product
safety information, and assistance with
product and ingredient development.
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ACC Supports Prioritization of
Chemicals
In reaction
to the recent hearing on “prioritization of
chemicals”, the American Chemistry Council
(ACC) sent a letter to Chairman Bobby Rush
and Ranking Member, George Radanovich of the
House Subcommittee on Commerce, Trade and
Consumer Protection to be submitted as part
of the record of the hearing on prioritizing
chemicals for safety determination.
The letter strongly endorsed prioritization
as a linchpin for modernization of the Toxic
Substances Control Act (TSCA).
Prioritization is the first step in a
program focused on providing for the safe,
beneficial use of chemicals as well as
boosting the public’s confidence in the
system. Adequate information about those
chemicals must be provided to the EPA in
order for all chemicals in commerce to be
prioritized.
The ACC released principles this summer
aimed at enhancing the manner in which
chemicals are managed in commerce. The
Council is working with Congress, the EPA
and a varied group of stakeholders to ensure
that the TSCA reform adheres to the priority
of public health, restores confidence in the
chemical regulatory system, reflects
scientific/technological advances, and
assures continued innovation from the U.S.
chemical industry.
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