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Chemical Information Services and Becker &
Associates Partner to Bring Life Science Chemistry
Databases Online
Chemical Information Services and
Becker & Associates announce their partnership
to launch the first online version of the full suite
of Becker Data. Currently available on CD-Rom, the
online version will debut at CPhI in October 2010 in
Hall 6, Stand NAP002.
Long known as an industry leader, Becker &
Associates has identified, analyzed and edited
the production processes of life science molecules
from basic commodities through the most complex fine
chemicals. The Becker databases provide a
comprehensive presentation of market and technology
interaction. The complex, expert information in
these databases is edited in state of the art
proprietary programs to enable easy and instant
access to the most intricate reaction data. This new
online version of Becker Data will allow subscribers
greater flexibility and additional search
functionality.
The suite of Becker databases are:

• Future Generics Database
• Pesticide Production Database
• Becker Intermediates Catalogue
• Conceptus Pharmaceutical Database
• Pharmaceutical Intermediates Database
Be sure to visit Becker & Associates at CPhI, Hall
6, Stand NAP002
To learn more about Becker Data, please contact
beckerdata@chemicalinfo.com

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“Anger so clouds the mind, that it cannot
perceive the truth.”
- Cato the Elder
“Catch a man a fish, and you can sell it to
him. Teach a man to fish, and you ruin a
wonderful business opportunity.”
- Karl Marx
“Don't let your ego get too close to your
position, so that if your position gets shot
down, your ego doesn't go with it. “
- Colin Powell
“A positive attitude may not solve all your
problems, but it will annoy enough people to
make it worth the effort.” - Herm Albright
“Competence, like truth, beauty and contact
lenses, is in the eye of the beholder.”
- Laurence J. Peter
“The superior man is modest in his speech,
but exceeds in his actions.”
-Confucius
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How Does
Adrenaline Work?
It is the “rush” that can
happen in an array of situations – whether
it is skydiving out of an airplane or giving
a speech in front of a crowd. The adrenaline
rush is the body’s natural response to a
threat. Known as the “fight or flight”
reaction, it is a physiological process that
prepares the body to react to emergencies.
Adrenaline is a hormone secreted by the
adrenal glands, which sit adjacent to the
top of each of the kidneys. Also known as
epinephrine, it is a key element in the
stimulation involved in the “fight or
flight” response. The hormone is produced by
dedicated adrenal chromaffin cells found in
the central part of the adrenal gland. The
gland is stimulated by various signals and
the hormone is secreted in response to the
stimuli. Acting on many cells of the body,
epinephrine behaves like a neurotransmitter,
transferring and regulating the signals
between the neurons and other cells. The
sympathetic nervous system (SNS), a
subdivision of the autonomic nervous system
(ANS) is responsible for the generation of
the response.
Consequences of epinephrine secretion are
numerous and many actions take place. The
muscles and the brain receive an increased
supply of oxygen and glucose, and there is a
rise in stroke volume as the heart rate
increases. The pupils dilate, arterioles in
the skin constrict, blood sugar levels
increase, and both the immune and digestive
systems are suppressed. The hormone is
necessary for the smooth functioning of the
body by helping to counter the stress
experienced during the emergent event. It
signals the nervous system to act
immediately. A quick reaction in times of
emergency is possible thanks to glucose
produced. The resulting energy enables the
body to react faster.
Jokichi Takamine and his assistant Keizo
Uenaka, both of Japan, discovered
epinephrine in 1900. Using the adrenal
glands of a cow, the isolation and
purification of epinephrine was carried out.
Friedrich Stolz produced epinephrine
artificially in 1904. Synthetic epinephrine
has many uses in medical emergencies like
shock, heart attacks, and asthma.
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Endotherm GmbH
Develops MurA Inhibitors
Endotherm Life Science Molecules is a
provider of medicinally relevant compounds
for the discovery and development of novel
small molecule drugs. The organization
recently took part in a successful joint
research project, performed by Endotherm
together with Prof. Dr. Ch. Klein from the
Universität Heidelberg, focused on the
development of new MurA inhibitors.
Endotherm contributed the design and
synthesis of focused target-based compound
libraries, the group from Prof. Ch. Klein
provided expertise concerning the expression
of the enzyme and biochemical assays to
evaluate Endotherm´s compounds regarding
their MurA inhibitory properties.
Antibiotic resistance, global warming and
intense travelling have lead to an increase
in the occurrence of infectious diseases
during the last 20 years. Within the past 40
years, only three new classes of antibiotic
compounds were discovered: cyclic
lipopeptides, glycylcyclines, and
oxazolidinones. A new approach to antibiotic
research to fight multi-drug tested
organisms (MDROs) is necessary to deal with
the resistant bacteria. In the research, two
basic approaches are followed for rational
drug discovery: The first one is to mimic a
phosphoenol-pyruvate, which in turn is one
of the natural substrates of MurA to be used
in the first biosynthesis step of cell wall
formation. The second involves providing a
transition state analogue of the natural
MurA-substrate-complex, consisting of UNAG (UDP-N-acetylglucosamine)
derivatives, may lead to the inhibition of
the enzyme. By contrast to fosfomycin,
resistance is likely not to be expected by
this mode of action. A significant number of
MurA inhibitors have been found which will
now have to be optimized by chemical
modification to also exhibit the desired
antibiotic activity.
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Landec
Subsidiary and Windset Farms Enter Into
License Agreement
Apio, Inc., a subsidiary of polymer science
company, Landec Corporation, has signed an
exclusive agreement with Greenhouse Grown
Foods Inc. (d/b/a Windset Farms) to license
its proprietary breathable packaging to
extend the shelf life of specific greenhouse
grown vegetables. Under terms of the
agreement, Apio will receive a one-time,
upfront R&D fee as well as ongoing licensing
fees from the revenue of the exclusive
products that utilize the technology, with
or without the BreatheWay® trademark.
Windset will have exclusive use of the
technology and the trademark for use in the
production, marketing, distribution, and
sale of the exclusive products in the United
States and Canada within the exclusive
licensed field. Apio will provide Windset
with the required technical services as well
as any additional support necessary for
future development of the technology.
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CleanTech
Biofuels Receives U.S. Patent
CleanTech Biofuels’ technology for
converting municipal solid waste (MSW) to
cellulosic biomass feedstock recently
received a U.S. patent. The patent covers
the company’s process and apparatus for the
conversion, known collectively as the
Biomass Recovery Process. The Biomass
Recovery Process is carried out by an angled
reaction vessel that utilizes steam and
pressure to both clean and separate MSW into
recyclables and lignocellulosic biomass
feedstock. Issuance of the patent
strengthens the company’s property portfolio
and places it in a position to take the lead
as a feedstock supplier to the renewable
energy and bio-based chemical industries. It
has the exclusive rights to the Biomass
Recovery Process in the U.S. and Canada,
subject to CleanTech’s exclusive licensing
agreement with Biomass North America LLC.
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Fuwei Films
Launches New Dry Film Product
Fuwei Films (Holdings) Co. Limited has
successfully launched a new dry film
product. The manufacturer and distributor of
high-quality BOPET plastic films located in
China, completed the development through its
wholly-owned subsidiary, Fuwei Films
(Shandong) Co. Ltd. The test sample has
passed the strict examination by Hitachi
Chemical Shanghai and Asahi ASEI. Fuwei is
one of only two major manufacturers in the
Chinese BOPET industry that currently
produce this kind of dry film, which is in
high demand in the global market. It is
generally used in PCB and FPC circuit board
production as well as in nameplate and
crafts etching.
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Songwon
Industrial Leads on Environmental Protection
and Energy Savings
Songwon Industrial Co. Ltd. recently
announced the start up of its third
incinerator and the installation of
photovoltaic solar panels at its Ulsan
production site. The new incinerator will be
used to burn VOC and to generate steam
required by the plant. Two incinerators are
already in use and help to safely eliminate
chemical residues and waste. The steam
generated by the process is used as an
energy source for the plant. The latest
state-of-the-art incinerator offers a new
patented technology that was jointly
developed by Songwon and the incinerator
supplier eTEC. It is designed to drastically
reduce any risk of explosion. Songwon also
completed the installation of its first set
of photovoltaic solar panels at its Ulsan
plant. These solar panels were installed to
reduce consumption of energy derived from
nonrenewable energy sources.
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DSM Presents
2010 Performance Materials Award to
Professor Han E.H. Meijer
Han E.H. Meijer,
Professor of Polymer Technology and
Scientific Director of the Research School
Eindhoven Polymer Laboratories at the
Eindhoven University of Technology in the
Netherlands, is the recipient of the DSM
Performance Materials Award 2010. Professor
Meijer received the recognition for his
exceptional contributions to the advancement
of the materials sciences. He is one of the
world’s leading scientists in the field of
predicting polymer structuring during
processing and the relation between
resulting structure and mechanical
performance.
The DSM Performance Materials Award forms
part of DSM’s Innovation Awards Program and
is presented in cooperation with the
International Union of Pure and Applied
Chemistry (IUPAC). The award is given every
two years in recognition of scientific work
that has significantly contributed to the
advancement of the materials sciences.

Air Products
Appoints Sustainability Manager
Air Products has appointed Julie O'Brien to
the position of Corporate Sustainability
Manager. O’Brien will be responsible for the
development and management of the company’s
worldwide sustainability initiatives,
practices, and reporting. She will work with
both senior business and functional managers
and Air Products' Sustainability Council to
drive achievements against the company's
sustainability growth strategy and
improvement targets. O’Brien joined Air
Products in 1986 and has served in a number
of roles.

Verenium
Announces Promotion of President and Chief
Operating Officer
Verenium Corporation has promoted Janet
Roemer to the position of President and
Chief Operating Officer of its Enzymes
Business. Roemer joined the company in March
of 2008. Prior to joining Verenium, Roemer
held several positions with the BP Group
including Chief of Staff to the CEO of
Innovene, a former division of BP Group and
Vice President and General Manager of a $1.7
billion North American chemical business.

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Xcelience
Forming Joint Venture with Penn Pharma
Xcelience, LLC announced that it is forming
a joint venture with Penn Pharma to provide
the precision powder micro-dosing system
technology, Capsugel’s Xcelodose®, on a
global basis. The Xcelodose® system allows
biotechnology and pharmaceutical companies
the ability to manufacture first in human
batches near clinical sites guaranteeing
immediate manufacturing capacity. Xcelience
is a contract research company providing
preformulation, formulation development, and
analytical and clinical trial manufacturing.
Penn Pharma provides pharmaceutical
development and custom manufacturing
services internationally to the healthcare
industry.
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Cabot
Corporation Acquires Oxonica Materials Inc.

Cabot Corporation (Cabot) has acquired
Oxonica Materials Inc. (OMI), a wholly-owned
subsidiary of Oxonica plc. The purchase
expands Cabot’s portfolio of security
technologies and will complement the
company’s existing securities business. OMI
develops Surface Enhanced Raman Scattering (SERS)
materials and detection methods. These SERS
materials provide highly
counterfeit-resistant security solutions for
a broad range of applications. Cabot's
Security Business is a leading supplier of
covert taggants, providing unique,
hard-to-replicate particles added to inks,
paper, films, and other materials that can
only be detected with a specialized reader.
Covert taggants are used to add additional
security features to applications from
passports to packaging.
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Clariant
Releases Second Quarter Performance
Information

Specialty chemical
leader, Clariant recently announced its
performance figures for the second quarter
of 2010. On the back of a broad economic
recovery, the company reported sales growth
in all businesses and regions, with an
increase of 18% in Swiss Francs and 20% in
local currency. The business units Pigments,
Additives, Leather, and Masterbatches
realized the most improved economic
environment and rose above group average.
Faced with the depreciation of the Euro
against the USD and an increased
competitiveness, demand in Europe developed
better compared to last year. This resulted
in a strong 22% sales growth for Clariant.
Demand in Asia, Latin and North America
increased, too, which had a favorable effect
on the company’s sales volumes. Clariant’s
gross margin significantly improved, up to
28.9% compared to 24.8% in the previous
year. Sale prices were increased by 1% to
make up for a 4% uptake in raw material
costs. However, these prices have not yet
fully compensated for feedstock markups, and
they will have to be intensified further in
coming months as further cost increases are
expected.
As part of its Global Asset Network
Optimization (GANO) efforts, Clariant is
improving the structure of its production
facilities and consolidating some of its
Pigment activities in Asia. Because of its
ongoing cost reduction focus, SG&A costs
dropped to 16.3% of sales, compared to 18.6%
last year. Operating income (EBIT) margin
before exceptional items improved 11.1% and
the company reported a net profit of CHF 25
million for the quarter, compared to a net
loss of CHF 61 million last year. Clariant’s
cash position remained strong at CHF 1,221
million.
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Afton Chemical’s
New Additive Exceeds Requirements
NewMarket Corporation’s wholly-owned
subsidiary, Afton Chemical Corporation, is
ready to launch a new passenger car motor
oil (PCMO) additive. This additive is one of
the first to come to market in anticipation
of the new GF-5 standard set by the
International Lubricant Standardization and
Approval Committee (ILSAC), which goes into
effect this coming October. The new additive
is also a cost effective solution for
meeting both GF-5 requirements as well as
the dexos1™ standard from General Motors.
The GF-5 additive will cover more viscosity
grades than the company’s GF-4 product and
will minimize the need for special base
stocks. It also exceeds the GF-5
specification in a number of key performance
areas. In the Sequence IIIG test for oil
robustness, the Afton additive demonstrated
almost a 20% better performance than the
GF-5 requirement. It also exceeded the GM
dexos1™ specification across a range of
industry base stocks. In the Opel RNT test,
used by GM for their dexos1™ requirement,
the product controlled camshaft wear to 3 to
4 atoms/hour, which is 65% better than the
limit set in the specification.
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PPG Aerospace
Coatings System Tops Milestone
PPG Aerospace’s
selectively strippable exterior
coatings system has topped an aircraft
milestone. British Airways is the recipient
of the 500th new aircraft painted with the
Desothane® system. Introduced on a
commercial aircraft in 1998, the system has
been chosen by over 30 airlines for their
aircraft. In airline maintenance operations,
the PPG system reduces painting downtime
because a primer is not removed during
selective stripping of the topcoat and
intermediate coat. In addition, it provides
corrosion protection for the airframe,
affords a high-gloss, durable finish and has
environmental benefits. The intermediate
coating in combination with the Desothane™
topcoat creates a highly flexible system,
resulting in improved rivet paint adhesion
and reduced paint film crazing. Since its
introduction, the system has reduced the
volume of organic solvent, thanks to the
efficiency of the stripping and repainting
process, and has eliminated the need for
toxic paint removers.
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